Mitochondrial Mutations: Newly Discovered Players in Neuronal Degeneration

Neuronal degeneration and mitochondrial dysfunction.

Functional Characterization of Newly-Discovered Mutations in Human SR-BI

In rodents, SR-BI has been firmly established as a physiologically relevant HDL receptor that mediates removal of HDL-cholesteryl esters (CE). However, its role in human lipoprotein metabolism is less defined. Recently, two unique point mutations in human SR-BI - S112F or T175A - were identified in subjects with high HDL-cholesterol (HDL-C) levels. We hypothesized that mutation of these conserv...

Newly Discovered Activities for Calcitriol

16 ROGERS, B. L., SOBNOSKY, M. G. & SAUNDERS, G. F. (1985). Transcriptional enhancer within the human placental lactogen and growth hormone multigene cluster. J . Biol. Chem. (in press). 17 PICARD, D. & SCHAFFNER, W. (1984). A lymphocyte-specific enhancer in the mouse immunoglobulin gene. Nature 307, 80-82. 18 EPHRUSSI, A., CHURCH, G. M., TONEGAWA, S. & GILBERT, W. (1985). Science 227, 134-140....

Newly discovered myokines in chronic kidney disease.

Newly discovered antiterminator RNAs in bacteriophage.

Antiterminator RNA directly modifies the transcription elongation complex so that it terminates less efficiently at intrinsic and factor-dependent terminators. These unusual RNAs were first discovered in bacteriophage HK022, where the nascent transcripts of the phage put sites promote full expression of phage genes during lytic infection. The activity of antiterminator RNA depends on specific s...